The École polytechnique fédérale de Lausanne (EPFL, English: Swiss Federal Institute of Technology in Lausanne) is one of the two Swiss Federal Institutes of Technology and is located in Lausanne, Switzerland.

EPFL is located in the French-speaking part of Switzerland; the sister institution in the German-speaking part of Switzerland is the Swiss Federal Institute of Technology in Zurich (ETH Zurich).

EPFL is considered to be among the world's most prestigious universities in technology. The three most influential and widely observed international university rankings, QS World University Rankings, Academic Ranking of World Universities and Times Higher Education World University Rankings ranks EPFL No. 2, #1 and No. 2 respectively in the field of Engineering and Technology on continental Europe in their 2013–2014 rankings. In the rankings EPFL competes with Cambridge, Oxford, Imperial College London and its rival sister-institution, ETH Zurich, for the European top five spots in Engineering and Technology.